GENETICS OF MITOCHONDRIAL DISEASES
نویسندگان
چکیده
منابع مشابه
Role of Mitochondrial Genetics in Complex Diseases
The study of genetic disease is often centered on the human nuclear genome consisting of ~3.1 billion nucleotides and 25,000–30,000 genes located on the 23 pairs of chromosomes, whereas the mitochondrial genome has received less attention. Each cell contains numerous mitochondria and each mitochondrion contains several copies of mitochondrial DNA (mtDNA). Thus, a cell contains several thousand ...
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INTRODUCTION In the last 10 years the field of mitochondrial genetics has widened, shifting the focus from rare sporadic, metabolic disease to the effects of mitochondrial DNA (mtDNA) variation in a growing spectrum of human disease. The aim of this review is to guide the reader through some key concepts regarding mitochondria before introducing both classic and emerging mitochondrial disorders...
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The mitochondrial genome is vital for Caenorhabditis elegans metabolism, physiology, and development. The C. elegans mitochondrial DNA is typical of animal mitochondrial genomes in its size and gene content. It is 13,794 nucleotides in length and encodes 36 genes: 2 ribosomal RNAs, 22 transfer RNAs, and 12 protein subunits of the mitochondrial respiratory chain. Although it represents only a sm...
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ژورنال
عنوان ژورنال: Brain
سال: 2004
ISSN: 1460-2156
DOI: 10.1093/brain/awh093